Posted by Spycor LLC on Dec 4th 2025

The requirement for compliant air quality in critical healthcare environments is non-negotiable. Whether managing patient infectious diseases in a hospital, protecting immunocompromised individuals in a clinic, or ensuring sterility in a specialized laboratory, maintaining precise air changes per hour (ACH) and high-efficiency particulate air (HEPA) filtration is paramount.
For organizations needing a permanent, out-of-the-way solution for infection control ventilation, the HEPA-CARE® Ceiling-Mounted Air Purification Systems offer the industry standard. Specifically, the HC800CD and HC500CD models provide the reliable, certified performance necessary to create and maintain CDC/CSA-compliant negative pressure isolation rooms.
Choosing between the HEPA-CARE HC800CD and the HC500CD, however, requires careful evaluation of your facility’s specific architectural, capacity, and operational needs. This comprehensive comparison will guide facility managers, engineers, and healthcare administrators in selecting the optimal ceiling-mounted HEPA air purification system to ensure patient safety and regulatory adherence.
The Critical Role of Ceiling-Mounted HEPA
Filtration in Infection Control
Traditional portable air scrubbers are effective but consume valuable floor space, pose tripping hazards, and can be cumbersome to maneuver. Ceiling-mounted HEPA air purification systems like the HEPA-CARE CD series solve these issues by utilizing existing drop-ceiling infrastructure.
By installing the filtration unit completely above the ceiling grid, these systems offer a permanent, hands-off solution for creating controlled air environments. They are dual-purpose tools, primarily used for:
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Negative Pressure Isolation: Drawing air out of a room and exhausting it outdoors (or into a return system), creating lower pressure inside to prevent airborne contaminants from escaping into corridors. This is essential for infectious disease management.
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Continuous Recirculating Air Purification: When not in negative pressure mode, the unit filters the room air internally, significantly lowering the overall microbial and particulate count, improving indoor air quality for high-risk patients.
Both the HC800CD and HC500CD utilize pharmaceutical-grade H14 HEPA filters, certified to capture a minimum of 99.995% of airborne particles 0.3 microns in size. This includes critical pathogens, spores, and microscopic infectious aerosols. The key to selection lies in the volume of air they can process—their capacity, measured in Cubic Feet per Minute (CFM).

Deep Dive: Introducing the HEPA-CARE
HC800CD System
The HC800CD is the powerhouse of the ceiling-mounted HEPA-CARE lineup, engineered for maximum capacity and demanding environments.
Power, Performance, and Ideal Use Cases
The HC800CD features two powerful, energy-efficient motorized impellers, giving it a superior airflow capability. It is designed to handle larger spaces or rooms requiring highly frequent air exchange cycles.
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Peak Capacity: 725 CFM up to 850 CFM.
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Isolation Room Performance: This high flow rate is typically capable of maintaining the required 12+ air changes per hour (ACH) in rooms as large as 3,625 to 4,250 cubic feet (a standard 10-foot ceiling room measuring approximately 20' x 21' to 20' x 25').
This robust capacity makes the HC800CD the ideal choice for:
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Larger Standard Patient Rooms: Where the combined volume of medical equipment and space demands higher CFM to maintain compliance.
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Hospital Anterooms/Vestibules: Providing dedicated negative pressure isolation for the entry space leading into a larger isolation suite.
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Operating Theatres (Temporary Isolation): Offering supplementary air filtration for hospitals during construction or when an OR must be temporarily converted for infectious procedures.
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ICUs and Critical Care Units: Where rapid and reliable pathogen removal is non-negotiable.
Installation Footprint
To accommodate its dual impeller system and high-capacity filter bank, the HC800CD unit requires a larger physical footprint, suspending neatly in a 2 ft. x 4 ft. drop ceiling grid space. While slightly larger, this above-ceiling installation ensures zero loss of floor area below.

Deep Dive: Introducing the HEPA-CARE
HC500CD System
The HC500CD model is designed for flexibility and efficiency, offering exceptional performance in smaller, more numerous critical spaces. It delivers the same certified HEPA filtration quality but in a more compact package.
Efficiency, Compactness, and Ideal Use Cases
The HC500CD uses a single, highly efficient motorized impeller, providing excellent airflow suitable for the majority of standard isolation room requirements. It maintains the same H14 HEPA filtration standards as its larger counterpart.
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Peak Capacity: 200 CFM up to 550 CFM.
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Isolation Room Performance: The HC500CD is capable of maintaining the crucial 12+ ACH threshold in standard isolation areas ranging from 2,500 to 3,000 cubic feet (approximately 15’ x 16’ to 15’ x 20’ with a 10-foot ceiling).
This balance of size and performance makes the HC500CD an excellent solution for:
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Standard Single-Patient Isolation Rooms: The most common application in hospitals, clinics, and long-term care facilities.
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Small Procedure Rooms and Labs: Areas requiring dedicated localized air quality control without excessive power.
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Outpatient and Emergency Department Clinics: When temporary or flexible negative pressure capabilities are needed immediately.
Installation Footprint
A primary advantage of the HC500CD is its highly compact size. The filtration module is designed to fit seamlessly into a standard 2 ft. x 2 ft. drop ceiling grid, requiring less space overhead and providing a solution when ceiling infrastructure is tighter or compartmentalized.
HC800CD vs HC500CD: A Feature-by-
Feature Comparison for Optimal Selection
When evaluating which ceiling-mounted air purification system is best for your facility, capacity and physical constraints are the primary differentiators. Both units share many crucial features that ensure compliance and ease of use, including:
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Filtration Integrity: Both use H14 HEPA filters (99.995% efficiency) with a zero-bypass silicone-gel seal to guarantee all air passes through the filter media.
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Control Panel: Both utilize a separate, tamper-resistant digital LCD touchscreen control panel that can be wall-mounted either near the unit or remotely. This allows staff to monitor status and adjust the five airflow settings without disturbing the ceiling unit.
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Noise Levels: Both systems operate quietly above the ceiling, with typical operating noise levels ranging from 35 dBA to 59 dBA @ 5 feet, minimizing disruption to patients and staff.
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Optional Upgrades: Both models accept optional VAPOR-LOCK® activated carbon filters for odor and chemical gas removal, and both can be paired with an optional UVGI Disinfection Module for germicidal UV-C irradiation, providing an extra layer of protection against airborne pathogens.
Here is a direct comparison of the critical technical specifications:
| Feature | HEPA-CARE® HC800CD | HEPA-CARE® HC500CD |
| Airflow (Peak CFM) |
725 CFM – 850 CFM | 200 CFM – 550 CFM |
| Max Room Volume (12 ACH) |
3,625 to 4,250 ft³ | 2,500 to 3,000 ft³ |
| Ceiling Footprint |
2 ft. x 4 ft. | 2 ft. x 2 ft. |
| Primary Motor Type |
Dual Motorized Impellers | Single Motorized Impeller |
| HEPA Filter Efficiency |
99.995% @ 0.3 microns (H14 Grade) | 99.995% @ 0.3 microns (H14 Grade) |
| Control System |
Remote Digital Touchscreen | Remote Digital Touchscreen |
| Typical Use |
Larger isolation suites, ICUs, high-volume areas. | Standard isolation rooms, smaller clinics, labs. |
Choosing the Right Capacity: ACH
Calculation and Compliance
The decision between the HC800CD and HC500CD ultimately hinges on your facility’s requirement for Air Changes Per Hour (ACH). Healthcare standards, such as those from the CDC, mandate that an isolation room must achieve a minimum of 12 ACH to ensure rapid removal of airborne infectious particles.
To determine which unit you need, calculate the room’s volume:

In this case, only the HC800CD (max 850 CFM) is guaranteed to meet the 12 ACH requirement reliably, especially as filters load up and static pressure increases. The HC500CD would be insufficient for this large isolation room.
By calculating your exact CFM needs based on the largest or most critical rooms requiring negative pressure room air scrubbers, you can accurately match your requirement to the powerful capabilities of the HEPA-CARE CD series. Investing in the appropriate model ensures your facility maintains regulatory compliance while providing the highest level of hospital air filtration and safety for patients and staff.
Order Now at spycor.com to secure the optimal HEPA-CARE ceiling-mounted HEPA air purification system for your specialized isolation room needs and elevate your facility's infection control ventilation standards.
Frequently Asked Questions (FAQ)
What is the primary difference between the HC800CD and HC500CD units?
The primary difference is airflow capacity (CFM) and physical size. The HC800CD provides higher airflow (up to 850 CFM) and fits a 2 ft. x 4 ft. ceiling grid, making it suitable for larger rooms (up to 4,250 ft³). The HC500CD provides up to 550 CFM and fits a compact 2 ft. x 2 ft. ceiling grid, ideal for standard-sized isolation rooms (up to 3,000 ft³).
Are these systems capable of creating negative pressure and positive pressure?
Yes. Both the HC800CD and HC500CD are flexible patient isolation systems. They can be used to create negative pressure (to contain airborne contaminants) or positive pressure (to protect immunocompromised patients from external contaminants) simply by adjusting the unit's exhaust mode and relative air flow with respect to the room HVAC system.
How often do the HEPA filters need to be changed?
The HEPA filter life depends heavily on the operating hours and the concentration of airborne contaminants being filtered. Both systems feature an intuitive digital control panel that includes a "Change HEPA Filter" indicator. This indicator illuminates when the filter reaches its load limit, ensuring it is only replaced when necessary, optimizing maintenance costs.
Do these HEPA-CARE models require any specialized electrical work?
The standard versions of both HC800CD and HC500CD operate on standard 120V power (Export 230V/50-60Hz versions are also available). However, as permanent, fixed installations, they must be wired by a qualified electrician in accordance with all local and national electrical codes.
Can these ceiling-mounted systems also remove odors and chemical fumes?
Yes. Both HEPA-CARE systems are compatible with optional VAPOR-LOCK® high-capacity activated carbon filters or carbon blend filters, which replace the standard pre-filter. These carbon filters are specifically designed to capture and neutralize odors, chemical gases, and volatile organic compounds (VOCs).
Why should I choose a ceiling-mounted unit over a portable air scrubber?
Ceiling-mounted units are preferred in fixed healthcare settings because they:
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Save valuable floor space.
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Reduce noise pollution within the patient environment (as the motor is above the ceiling).
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Offer a permanent, reliable, and tamper-resistant solution for long-term infection control.